Human ARHGEF11 activation kit by CRISPRa

CAT#: GA106622

ARHGEF11 CRISPRa kit - CRISPR gene activation of human Rho guanine nucleotide exchange factor 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGEF11
• Locus ID: 9826
• Kit Components:

  GA106622G1, ARHGEF11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106622G2, ARHGEF11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106622G3, ARHGEF11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014784, NM_198236
• Synonyms: GTRAP48; PDZ-RHOGEF
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]