Human SPG48 (AP5Z1) activation kit by CRISPRa

CAT#: GA106693

AP5Z1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 5 subunit zeta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AP5Z1
• Locus ID: 9907
• Kit Components:

  GA106693G1, AP5Z1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106693G2, AP5Z1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106693G3, AP5Z1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014855, NM_001364858, NR_157345
• Synonyms: KIAA0415; SPG48; zeta
• Summary: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]