Human TL1A (TNFSF15) activation kit by CRISPRa

CAT#: GA106744

TNFSF15 CRISPRa kit - CRISPR gene activation of human TNF superfamily member 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFSF15
• Locus ID: 9966
• Kit Components:

  GA106744G1, TNFSF15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106744G2, TNFSF15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106744G3, TNFSF15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204344, NM_005118
• Synonyms: TL1; TL1A; TNLG1B; VEGI; VEGI192A
• Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]