Human Constitutive androstane receptor (NR1I3) activation kit by CRISPRa

CAT#: GA106748

NR1I3 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 1 group I member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR1I3
• Locus ID: 9970
• Kit Components:

  GA106748G1, NR1I3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106748G2, NR1I3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106748G3, NR1I3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077469, NM_001077470, NM_001077471, NM_001077472, NM_001077473, NM_001077474, NM_001077475, NM_001077476, NM_001077477, NM_001077478, NM_001077479, NM_001077480, NM_001077481, NM_001077482, NM_005122
• Synonyms: CAR; CAR1; MB67
• Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]