Human HNRPDL (HNRNPDL) activation kit by CRISPRa

CAT#: GA106760

HNRNPDL CRISPRa kit - CRISPR gene activation of human heterogeneous nuclear ribonucleoprotein D like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNRNPDL
• Locus ID: 9987
• Kit Components:

  GA106760G1, HNRNPDL gRNA vector 1 in pCas-Guide-CRISPRa

  GA106760G2, HNRNPDL gRNA vector 2 in pCas-Guide-CRISPRa

  GA106760G3, HNRNPDL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001207000, NM_005463, NM_031372, NR_003249
• Synonyms: HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1; LGMD1G
• Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]