Human FLASH (CASP8AP2) activation kit by CRISPRa

CAT#: GA106767

CASP8AP2 CRISPRa kit - CRISPR gene activation of human caspase 8 associated protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP8AP2
• Locus ID: 9994
• Kit Components:

  GA106767G1, CASP8AP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106767G2, CASP8AP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106767G3, CASP8AP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001137667, NM_001137668, NM_012115
• Synonyms: CED-4; FLASH; RIP25
• Summary: This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2008]