Human DRP1 (DNM1L) activation kit by CRISPRa

CAT#: GA106816

DNM1L CRISPRa kit - CRISPR gene activation of human dynamin 1 like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNM1L
• Locus ID: 10059
• Kit Components:

  GA106816G1, DNM1L gRNA vector 1 in pCas-Guide-CRISPRa

  GA106816G2, DNM1L gRNA vector 2 in pCas-Guide-CRISPRa

  GA106816G3, DNM1L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278463, NM_001278464, NM_001278465, NM_001278466, NM_001330380, NM_005690, NM_012062, NM_012063
• Synonyms: DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV
• Summary: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]