Human RAD50 activation kit by CRISPRa

CAT#: GA106859

RAD50 CRISPRa kit - CRISPR gene activation of human RAD50 double strand break repair protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD50
• Locus ID: 10111
• Kit Components:

  GA106859G1, RAD50 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106859G2, RAD50 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106859G3, RAD50 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005732, NM_133482
• Synonyms: hRad50; NBSLD; RAD502
• Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. [provided by RefSeq, Apr 2010]