Human OLIG2 activation kit by CRISPRa

CAT#: GA106945

OLIG2 CRISPRa kit - CRISPR gene activation of human oligodendrocyte transcription factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OLIG2
• Locus ID: 10215
• Kit Components:

  GA106945G1, OLIG2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106945G2, OLIG2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106945G3, OLIG2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005806
• Synonyms: BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17
• Summary: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]