Human MRP4 (ABCC4) activation kit by CRISPRa

CAT#: GA106984

ABCC4 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABCC4
• Locus ID: 10257
• Kit Components:

  GA106984G1, ABCC4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106984G2, ABCC4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106984G3, ABCC4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001105515, NM_001301829, NM_001301830, NM_005845
• Synonyms: MOAT-B; MOATB; MRP4
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]