Human CBARA1 (MICU1) activation kit by CRISPRa

CAT#: GA107063

MICU1 CRISPRa kit - CRISPR gene activation of human mitochondrial calcium uptake 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MICU1
• Locus ID: 10367
• Kit Components:

  GA107063G1, MICU1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107063G2, MICU1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107063G3, MICU1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195518, NM_001195519, NM_006077, NM_001363513
• Synonyms: CALC; CBARA1; EFHA3; MPXPS
• Summary: This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]