Human Cyclophilin E (PPIE) activation kit by CRISPRa

CAT#: GA107127

PPIE CRISPRa kit - CRISPR gene activation of human peptidylprolyl isomerase E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPIE
• Locus ID: 10450
• Kit Components:

  GA107127G1, PPIE gRNA vector 1 in pCas-Guide-CRISPRa

  GA107127G2, PPIE gRNA vector 2 in pCas-Guide-CRISPRa

  GA107127G3, PPIE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195007, NM_001319293, NM_006112, NM_203456, NM_203457, NR_036543, NR_036544
• Synonyms: CYP-33; CYP33
• Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]