Human UBE2E3 activation kit by CRISPRa

CAT#: GA107152

UBE2E3 CRISPRa kit - CRISPR gene activation of human ubiquitin conjugating enzyme E2 E3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBE2E3
• Locus ID: 10477
• Kit Components:

  GA107152G1, UBE2E3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107152G2, UBE2E3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107152G3, UBE2E3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278554, NM_001278555, NM_006357, NM_182678
• Synonyms: UBCH9; UbcM2
• Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]