Human Semaphorin 4D (SEMA4D) activation kit by CRISPRa

CAT#: GA107177

SEMA4D CRISPRa kit - CRISPR gene activation of human semaphorin 4D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEMA4D
• Locus ID: 10507
• Kit Components:

  GA107177G1, SEMA4D gRNA vector 1 in pCas-Guide-CRISPRa

  GA107177G2, SEMA4D gRNA vector 2 in pCas-Guide-CRISPRa

  GA107177G3, SEMA4D gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142287, NM_006378
• Synonyms: C9orf164; CD100; coll-4; M-sema-G; SEMAJ
• Summary: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. [UniProtKB/Swiss-Prot Function]