Human NOL5A (NOP56) activation kit by CRISPRa

CAT#: GA107194

NOP56 CRISPRa kit - CRISPR gene activation of human NOP56 ribonucleoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NOP56
• Locus ID: 10528
• Kit Components:

  GA107194G1, NOP56 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107194G2, NOP56 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107194G3, NOP56 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006392, NR_027700, NR_145428
• Synonyms: NOL5A; SCA36
• Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]