Human Ribonuclease H2, subunit A (RNASEH2A) activation kit by CRISPRa

CAT#: GA107199

RNASEH2A CRISPRa kit - CRISPR gene activation of human ribonuclease H2 subunit A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNASEH2A
• Locus ID: 10535
• Kit Components:

  GA107199G1, RNASEH2A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107199G2, RNASEH2A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107199G3, RNASEH2A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006397
• Synonyms: AGS4; JUNB; RNASEHI; RNHIA; RNHL
• Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. [provided by RefSeq, Aug 2009]