Human SIVA (SIVA1) activation kit by CRISPRa

CAT#: GA107231

SIVA1 CRISPRa kit - CRISPR gene activation of human SIVA1 apoptosis inducing factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIVA1
• Locus ID: 10572
• Kit Components:

  GA107231G1, SIVA1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107231G2, SIVA1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107231G3, SIVA1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006427, NM_021709
• Synonyms: CD27BP; SIVA; Siva-1; Siva-2
• Summary: This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]