Human MTHFS activation kit by CRISPRa

CAT#: GA107245

MTHFS CRISPRa kit - CRISPR gene activation of human methenyltetrahydrofolate synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTHFS
• Locus ID: 10588
• Kit Components:

  GA107245G1, MTHFS gRNA vector 1 in pCas-Guide-CRISPRa

  GA107245G2, MTHFS gRNA vector 2 in pCas-Guide-CRISPRa

  GA107245G3, MTHFS gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199758, NM_006441, NR_037654
• Synonyms: HsT19268
• Summary: The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]