Human AHA1 (AHSA1) activation kit by CRISPRa

CAT#: GA107253

AHSA1 CRISPRa kit - CRISPR gene activation of human activator of HSP90 ATPase activity 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AHSA1
• Locus ID: 10598
• Kit Components:

  GA107253G1, AHSA1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107253G2, AHSA1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107253G3, AHSA1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012111, NM_001321441
• Synonyms: AHA1; C14orf3; p38
• Summary: Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). [UniProtKB/Swiss-Prot Function]