Human HBS1L activation kit by CRISPRa

CAT#: GA107377

HBS1L CRISPRa kit - CRISPR gene activation of human HBS1 like translational GTPase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HBS1L
• Locus ID: 10767
• Kit Components:

  GA107377G1, HBS1L gRNA vector 1 in pCas-Guide-CRISPRa

  GA107377G2, HBS1L gRNA vector 2 in pCas-Guide-CRISPRa

  GA107377G3, HBS1L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145158, NM_001145207, NM_006620, NM_001363686
• Synonyms: EF-1a; eRF3c; ERFS; HBS1; HSPC276
• Summary: This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]