Human RNPS1 activation kit by CRISPRa

CAT#: GA107489

RNPS1 CRISPRa kit - CRISPR gene activation of human RNA binding protein with serine rich domain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNPS1
• Locus ID: 10921
• Kit Components:

  GA107489G1, RNPS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107489G2, RNPS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107489G3, RNPS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286625, NM_001286626, NM_001286627, NM_006711, NM_080594, NR_104485
• Synonyms: E5.1
• Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]