Human RASSF1 activation kit by CRISPRa

CAT#: GA107707

RASSF1 CRISPRa kit - CRISPR gene activation of human Ras association domain family member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RASSF1
• Locus ID: 11186
• Kit Components:

  GA107707G1, RASSF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107707G2, RASSF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107707G3, RASSF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206957, NM_007182, NM_170712, NM_170713, NM_170714, NM_170715, NM_170716, NM_170717
• Synonyms: 123F2; NORE2A; RASSF1A; RDA32; REH3P21
• Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]