Human SEC63 activation kit by CRISPRa

CAT#: GA107737

SEC63 CRISPRa kit - CRISPR gene activation of human SEC63 homolog, protein translocation regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEC63
• Locus ID: 11231
• Kit Components:

  GA107737G1, SEC63 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107737G2, SEC63 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107737G3, SEC63 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007214, NM_018529
• Synonyms: DNAJC23; ERdj2; PRO2507; SEC63L
• Summary: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]