Human POLG2 activation kit by CRISPRa

CAT#: GA107738

POLG2 CRISPRa kit - CRISPR gene activation of human DNA polymerase gamma 2, accessory subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POLG2
• Locus ID: 11232
• Kit Components:

  GA107738G1, POLG2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107738G2, POLG2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107738G3, POLG2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007215
• Synonyms: HP55; MTPOLB; PEOA4; POLB; POLG-BETA; POLGB
• Summary: This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions. [provided by RefSeq, Sep 2009]