Human GPR44 (PTGDR2) activation kit by CRISPRa

CAT#: GA107752

PTGDR2 CRISPRa kit - CRISPR gene activation of human prostaglandin D2 receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTGDR2
• Locus ID: 11251
• Kit Components:

  GA107752G1, PTGDR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107752G2, PTGDR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107752G3, PTGDR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004778
• Synonyms: CD294; CRTH2; DL1R; DP2; GPR44
• Summary: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility. [provided by RefSeq, Mar 2011]