Human MAN1B1 activation kit by CRISPRa

CAT#: GA107754

MAN1B1 CRISPRa kit - CRISPR gene activation of human mannosidase alpha class 1B member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAN1B1
• Locus ID: 11253
• Kit Components:

  GA107754G1, MAN1B1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107754G2, MAN1B1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107754G3, MAN1B1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007230, NM_016219, NR_045720, NR_045721
• Synonyms: DKFZP434I213; MANA-ER
• Summary: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]