Human DDX19B activation kit by CRISPRa

CAT#: GA107765

DDX19B CRISPRa kit - CRISPR gene activation of human DEAD-box helicase 19B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DDX19B
• Locus ID: 11269
• Kit Components:

  GA107765G1, DDX19B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107765G2, DDX19B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107765G3, DDX19B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014449, NM_001014451, NM_001257172, NM_001257173, NM_001257174, NM_001257175, NM_007242, NM_001363938
• Synonyms: DBP5; DDX19; RNAh
• Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]