Human MGAT4A activation kit by CRISPRa

CAT#: GA107790

MGAT4A CRISPRa kit - CRISPR gene activation of human alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MGAT4A
• Locus ID: 11320
• Kit Components:

  GA107790G1, MGAT4A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107790G2, MGAT4A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107790G3, MGAT4A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160154, NM_012214
• Synonyms: GnT-4a; GNT-IV; GNT-IVA
• Summary: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]