Human KPI2 (LMTK2) activation kit by CRISPRa

CAT#: GA107855

LMTK2 CRISPRa kit - CRISPR gene activation of human lemur tyrosine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LMTK2
• Locus ID: 22853
• Kit Components:

  GA107855G1, LMTK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107855G2, LMTK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107855G3, LMTK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014916
• Synonyms: AATYK2; BREK; cprk; hBREK; KPI-2; KPI2; LMR2; PPP1R100
• Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]