Human ZCWCC1 (MORC2) activation kit by CRISPRa

CAT#: GA107878

MORC2 CRISPRa kit - CRISPR gene activation of human MORC family CW-type zinc finger 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MORC2
• Locus ID: 22880
• Kit Components:

  GA107878G1, MORC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107878G2, MORC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107878G3, MORC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303256, NM_001303257, NM_014941
• Synonyms: CMT2Z; ZCW3; ZCWCC1
• Summary: This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]