Human TCP1 epsilon (CCT5) activation kit by CRISPRa

CAT#: GA107932

CCT5 CRISPRa kit - CRISPR gene activation of human chaperonin containing TCP1 subunit 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCT5
• Locus ID: 22948
• Kit Components:

  GA107932G1, CCT5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107932G2, CCT5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107932G3, CCT5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306153, NM_001306154, NM_001306155, NM_001306156, NM_012073
• Synonyms: CCT-epsilon; CCTE; HEL-S-69; PNAS-102; TCP-1-epsilon
• Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]