Human IQSEC2 activation kit by CRISPRa

CAT#: GA108035

IQSEC2 CRISPRa kit - CRISPR gene activation of human IQ motif and Sec7 domain 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IQSEC2
• Locus ID: 23096
• Kit Components:

  GA108035G1, IQSEC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108035G2, IQSEC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108035G3, IQSEC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111125, NM_001243197, NM_015075, NR_024449
• Synonyms: BRAG1; MRX1
• Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]