Human SZT2 activation kit by CRISPRa

CAT#: GA108228

SZT2 CRISPRa kit - CRISPR gene activation of human SZT2 subunit of KICSTOR complex

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SZT2
• Locus ID: 23334
• Kit Components:

  GA108228G1, SZT2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108228G2, SZT2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108228G3, SZT2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015284, NM_024547, NM_001365999
• Synonyms: C1orf84; EIEE18; KIAA0467; SZT2A; SZT2B
• Summary: The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]