Human ADNP activation kit by CRISPRa

CAT#: GA108274

ADNP CRISPRa kit - CRISPR gene activation of human activity dependent neuroprotector homeobox

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADNP
• Locus ID: 23394
• Kit Components:

  GA108274G1, ADNP gRNA vector 1 in pCas-Guide-CRISPRa

  GA108274G2, ADNP gRNA vector 2 in pCas-Guide-CRISPRa

  GA108274G3, ADNP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282531, NM_001282532, NM_015339, NM_181442, NM_001347511
• Synonyms: ADNP1; HVDAS; MRD28
• Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]