Human SIRT1 activation kit by CRISPRa

CAT#: GA108289

SIRT1 CRISPRa kit - CRISPR gene activation of human sirtuin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIRT1
• Locus ID: 23411
• Kit Components:

  GA108289G1, SIRT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108289G2, SIRT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108289G3, SIRT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142498, NM_001314049, NM_012238
• Synonyms: SIR2; SIR2alpha; SIR2L1
• Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]