Human HP1 alpha (CBX5) activation kit by CRISPRa

CAT#: GA108327

CBX5 CRISPRa kit - CRISPR gene activation of human chromobox 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CBX5
• Locus ID: 23468
• Kit Components:

  GA108327G1, CBX5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108327G2, CBX5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108327G3, CBX5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127321, NM_001127322, NM_012117
• Synonyms: HEL25; HP1; HP1A
• Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]