Human RBFOX2 activation kit by CRISPRa

CAT#: GA108383

RBFOX2 CRISPRa kit - CRISPR gene activation of human RNA binding fox-1 homolog 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RBFOX2
• Locus ID: 23543
• Kit Components:

  GA108383G1, RBFOX2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108383G2, RBFOX2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108383G3, RBFOX2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001031695, NM_001082576, NM_001082577, NM_001082578, NM_001082579, NM_014309, NM_001349982, NM_001349983, NM_001349989, NM_001349990, NM_001349991, NM_001349992, NM_001349994, NM_001349995, NM_001349996, NM_001349997, NM_001349998, NM_001349999
• Synonyms: dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2; HRNBP2; RBM9; RTA
• Summary: This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]