Human Neurotensin Receptor 2 (NTSR2) activation kit by CRISPRa

CAT#: GA108439

NTSR2 CRISPRa kit - CRISPR gene activation of human neurotensin receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NTSR2
• Locus ID: 23620
• Kit Components:

  GA108439G1, NTSR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108439G2, NTSR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108439G3, NTSR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012344
• Synonyms: NTR2
• Summary: The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]