Human LYPLA3 (PLA2G15) activation kit by CRISPRa

CAT#: GA108466

PLA2G15 CRISPRa kit - CRISPR gene activation of human phospholipase A2 group XV

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLA2G15
• Locus ID: 23659
• Kit Components:

  GA108466G1, PLA2G15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108466G2, PLA2G15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108466G3, PLA2G15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012320, NM_001363551
• Synonyms: ACS; GXVPLA2; LLPL; LPLA2; LYPLA3
• Summary: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]