Human AIPL1 activation kit by CRISPRa

CAT#: GA108487

AIPL1 CRISPRa kit - CRISPR gene activation of human aryl hydrocarbon receptor interacting protein like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AIPL1
• Locus ID: 23746
• Kit Components:

  GA108487G1, AIPL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108487G2, AIPL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108487G3, AIPL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033054, NM_001033055, NM_001285399, NM_001285400, NM_001285401, NM_001285402, NM_001285403, NM_014336
• Synonyms: AIPL2; LCA4
• Summary: Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]