Human IBTK activation kit by CRISPRa

CAT#: GA108683

IBTK CRISPRa kit - CRISPR gene activation of human inhibitor of Bruton tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IBTK
• Locus ID: 25998
• Kit Components:

  GA108683G1, IBTK gRNA vector 1 in pCas-Guide-CRISPRa

  GA108683G2, IBTK gRNA vector 2 in pCas-Guide-CRISPRa

  GA108683G3, IBTK gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300906, NM_015525
• Synonyms: BTBD26; BTKI
• Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]