Human ANKRD17 activation kit by CRISPRa

CAT#: GA108728

ANKRD17 CRISPRa kit - CRISPR gene activation of human ankyrin repeat domain 17

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ANKRD17
• Locus ID: 26057
• Kit Components:

  GA108728G1, ANKRD17 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108728G2, ANKRD17 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108728G3, ANKRD17 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286771, NM_015574, NM_032217, NM_198889
• Synonyms: GTAR; MASK2; NY-BR-16
• Summary: The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]