Human ABHD12 activation kit by CRISPRa

CAT#: GA108744

ABHD12 CRISPRa kit - CRISPR gene activation of human abhydrolase domain containing 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABHD12
• Locus ID: 26090
• Kit Components:

  GA108744G1, ABHD12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108744G2, ABHD12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108744G3, ABHD12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042472, NM_015600
• Synonyms: ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC
• Summary: This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2011]