Human HERC4 activation kit by CRISPRa

CAT#: GA108745

HERC4 CRISPRa kit - CRISPR gene activation of human HECT and RLD domain containing E3 ubiquitin protein ligase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HERC4
• Locus ID: 26091
• Kit Components:

  GA108745G1, HERC4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108745G2, HERC4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108745G3, HERC4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017972, NM_001278185, NM_001278186, NM_001278187, NM_015601, NM_022079
• Synonyms: DKFZP564G092; KIAA1593
• Summary: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). [supplied by OMIM, Mar 2008]