Human SPAG8 activation kit by CRISPRa

CAT#: GA108796

SPAG8 CRISPRa kit - CRISPR gene activation of human sperm associated antigen 8

SDS

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Find the corresponding CRISPRi Inhibitor Kit

USD 1,290.00

2 Weeks*

Size
    • 1 kit

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Specifications

Product Data
Format 3gRNAs, 1 scramble ctrl and 1 enhancer vector
Symbol SPAG8
Locus ID 26206
Kit Components

GA108796G1, SPAG8 gRNA vector 1 in pCas-Guide-CRISPRa

GA108796G2, SPAG8 gRNA vector 2 in pCas-Guide-CRISPRa

GA108796G3, SPAG8 gRNA vector 3 in pCas-Guide-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100058
Disclaimer The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001039592, NM_012436, NM_172312, NM_001366760, NR_159431
Synonyms BS-84; CILD28; CT142; HSD-1; hSMP-1; SMP1; SPAG3
Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012]

Other Versions

SKU Description Size Price
KN405240 SPAG8 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
    • 1 kit

USD 1,290.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.