Human ARFGAP3 activation kit by CRISPRa

CAT#: GA108846

ARFGAP3 CRISPRa kit - CRISPR gene activation of human ADP ribosylation factor GTPase activating protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARFGAP3
• Locus ID: 26286
• Kit Components:

  GA108846G1, ARFGAP3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108846G2, ARFGAP3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108846G3, ARFGAP3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142293, NM_014570
• Synonyms: ARFGAP1
• Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]