Human ITGB1BP2 activation kit by CRISPRa

CAT#: GA108902

ITGB1BP2 CRISPRa kit - CRISPR gene activation of human integrin subunit beta 1 binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGB1BP2
• Locus ID: 26548
• Kit Components:

  GA108902G1, ITGB1BP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108902G2, ITGB1BP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108902G3, ITGB1BP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303277, NM_012278
• Synonyms: CHORDC3; ITGB1BP; MELUSIN; MSTP015
• Summary: This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]