Human AATF activation kit by CRISPRa

CAT#: GA108903

AATF CRISPRa kit - CRISPR gene activation of human apoptosis antagonizing transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AATF
• Locus ID: 26574
• Kit Components:

  GA108903G1, AATF gRNA vector 1 in pCas-Guide-CRISPRa

  GA108903G2, AATF gRNA vector 2 in pCas-Guide-CRISPRa

  GA108903G3, AATF gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012138
• Synonyms: BFR2; CHE-1; CHE1; DED
• Summary: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]