Human BSCL2 activation kit by CRISPRa

CAT#: GA108909

BSCL2 CRISPRa kit - CRISPR gene activation of human BSCL2 lipid droplet biogenesis associated, seipin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BSCL2
• Locus ID: 26580
• Kit Components:

  GA108909G1, BSCL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108909G2, BSCL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108909G3, BSCL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001122955, NM_001130702, NM_032667, NR_037948, NR_037949
• Synonyms: GNG3LG; HMN5; PELD; SPG17
• Summary: This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2). [provided by RefSeq, Mar 2011]