Human Neurobeachin (NBEA) activation kit by CRISPRa

CAT#: GA108949

NBEA CRISPRa kit - CRISPR gene activation of human neurobeachin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NBEA
• Locus ID: 26960
• Kit Components:

  GA108949G1, NBEA gRNA vector 1 in pCas-Guide-CRISPRa

  GA108949G2, NBEA gRNA vector 2 in pCas-Guide-CRISPRa

  GA108949G3, NBEA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204197, NM_015678
• Synonyms: BCL8B; LYST2
• Summary: This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined. [provided by RefSeq, Feb 2011]